The largest thing we have lost IMHO is the technology lead for the "new world order" or how things will be in ten, twenty, fifty years et al.
China, India, Germany, France, et al are taking the lead on alternative energy. We need to get away from drill baby drill to windmills, windfarms, safe nuclear power, Solar, biofuels, et al.
We are loosing our leadership position in the world, which scares me far more than what we have lost.
Also, we've dug ourselves so far into debt that we won't be able to recapitalize to move forward. Fifty years ago we were the people who responded to Sputnik by putting a man on the moon. Right now we're trying to respond to our crises by putting a mom into a mall to shop...we've fallen SO FAR IMHO.
Okay, off the rant.
More sadly than anything, I wish GM had kept a lead in excellent small trucks, with a world class S-10 replacement.
Wish the Malibu came with more bodystyles, a la the G6.
Wish Buick had a full lineup in place before they killed Pontiac. Was getting the Miata washed at the car wash today (usually wash it myself) and the woman behind me was getting her CTS washed. We started taling cars, and we both talked about how hot the new Lacrosse is. Woman is probably my mothers age, and I'm 44. She didn't want to buy the new LaCrosse because she thought of Buicks as "Old Peoples Cars." She's been a GM customer since the 1960's and she doesn't see a Buick as youthful enough for her....hmmm.
We've lost the next generation of hot rodders and customizers and racers. Seems like the younger generation is moving away from cars. I have three teenage children, and seems like a whole lot of their friends are just not into cars.
My two cents.
Chris